Glucosamine sulphate supplementation reduces symptoms of OA in placebo-controlled study

J.Y. Reginster, et al., published the findings of their glucosamine trial with osteoarthritis patients in the Jan.27, 2001 issue of Lancet. In this study of 212 patients with osteoarthritis of the knee joints, 106 patients were given glucosamine sulphate (1,500mg per day) and 106 patients were given the placebo. This three-year study demonstrated that glucosamine sulfate halted the further progression of knee arthritis as revealed by radiographs, whereas the placebo group had progressive joint space narrowing throughout the study period. As assessed by Western Ontario and McMaster Universities (WOMAC) scores, symptoms worsened slightly in the placebo group, compared with improvement of symptoms in patients using glucosamine. Glucosamine was well tolerated, and the dropout rate was small and equivalent to that of the placebo group.

The conclusion drawn by these researchers is that the long-term combined structure-modifying and symptom-modifying effects of glucosamine sulphate suggest it could be a disease-modifying agent in osteoarthritis.

Copyright Dynamic Chiropractic Jan 1, 2002
 

By James Meschino,DC,MS

Extracted from www.findarticles.com.

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